Due to the risk of addiction associated with the prolonged use of prescription opioids, there is an urgent need for non-opioid alternatives for the treatment of chronic pain.
Drugs such as dexmedetomidine that bind to the norepinephrine alpha-2a (α2a) adrenergic receptor are effective analgesics, but their sedative effects limit their widespread use.
A recent study used computational methods to identify novel compounds that could activate α2a-adrenergic receptors to relieve pain in mouse models without causing sedation.
Further research is needed to assess the side effects of these drugs and optimize the compounds for therapeutic use.
Full article: https://www.medicalnewstoday.com/articles/chronic-pain-non-opioid-drug-candidates-could-offer-relief-without-addiction?fbclid=IwAR2s5lEuyvwcBzCwUkhQ2yeFDypcaVfSPe1hXELvI1aDcOvkno-aXwbTses