• Due to the risk of addiction associated with the prolonged use of prescription opioids, there is an urgent need for non-opioid alternatives for the treatment of chronic pain.


  • Drugs such as dexmedetomidine that bind to the norepinephrine alpha-2a (α2a) adrenergic receptor are effective analgesics, but their sedative effects limit their widespread use.


  • A recent study used computational methods to identify novel compounds that could activate α2a-adrenergic receptors to relieve pain in mouse models without causing sedation.


  • Further research is needed to assess the side effects of these drugs and optimize the compounds for therapeutic use.


Full article: https://www.medicalnewstoday.com/articles/chronic-pain-non-opioid-drug-candidates-could-offer-relief-without-addiction?fbclid=IwAR2s5lEuyvwcBzCwUkhQ2yeFDypcaVfSPe1hXELvI1aDcOvkno-aXwbTses
Source: https://www.medicalnewstoday.com/


A National Institutes of Health-funded study has found that people with food allergies are less likely to become infected with SARS-CoV-2, the virus that causes COVID-19, than people without them. In addition, while previous research identified obesity as a risk factor for severe COVID-19, the new study has identified obesity and high body mass index (BMI) as associated with increased risk for SARS-CoV-2 infection. In contrast, the study determined that asthma does not increase risk for SARS-CoV-2 infection.


Source: https://www.sciencedaily.com/ 

Full Article: https://www.sciencedaily.com/releases/2022/06/220601092223.htm


Children with high-risk neuroblastoma had worse outcomes if they were from certain racial/ethnic groups or were on public rather than private insurance, despite being treated in clinical trials with standardized protocols, according to a study led by investigators from Dana-Farber/Boston Children's Cancer and Blood Disorders Center.

The study shows that young patients from historically marginalized populations or from lower-income backgrounds had poorer five-year survival rates even when they were assigned to receive uniform initial treatment after diagnosis with high-risk neuroblastoma.

"These findings recapitulate what we have known for decades at the population level-;children from historically marginalized groups are less likely to survive their cancer. They add an essential next layer to our understanding of racial and ethnic disparities in childhood cancer, and that is that enrollment on clinical trials is not enough to achieve racial and ethnic equity in survival."

Puja J. Umaretiya, MD, a clinical fellow in pediatric hematology/oncology at Dana-Farber/Boston Children's

Read more: Children from historically marginalized groups or poor backgrounds less likely to survive...

Research News

Featured Links